Adult Stem Cell Heart Failure Miracle?

[scmurphy3]

I saw this video http://www.youtube.com/watch?v=PcFQeRNuPDo on youtube that shows a patient with heart failure significantly improve. 

This, along with numerous published clinical trials strongly support the use of adult stem cells for heart failure.  See below a double blind clinical trial

Eur Heart J. 2006 Dec;27(23):2775-83. Epub 2006 Nov 10. Links
Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial.Schächinger V, Erbs S, Elsässer A, Haberbosch W, Hambrecht R, Hölschermann H, Yu J, Corti R, Mathey DG, Hamm CW, Süselbeck T, Werner N, Haase J, Neuzner J, Germing A, Mark B, Assmus B, Tonn T, Dimmeler S, Zeiher AM; REPAIR-AMI Investigators.
J. W. Goethe Universität Frankfurt, Med. Klinik III, Abt. Kardiologie, Theodor-Stern-Kai 7, 60590 Frankfurt a. M., Germany.

AIMS: To investigate the clinical outcome after intracoronary administration of autologous progenitor cells in patients with acute myocardial infarction (AMI). METHODS AND RESULTS: Using a double-blind, placebo-controlled multicentre trial design, we randomized 204 patients with successfully reperfused AMI to receive intracoronary infusion of bone-marrow-derived progenitor cells (BMCs) or placebo medium into the infarct artery 3-7 days after successful infarct reperfusion therapy. At 12 months, the pre-specified cumulative endpoint of death, myocardial infarction, or necessity for revascularization was significantly reduced in the BMC group compared with placebo (P=0.009). Likewise, the combined endpoint death, recurrence of myocardial infarction, and rehospitalization for heart failure was significantly (P=0.006) reduced in patients receiving intracoronary BMC administration. Intracoronary administration of BMC remained a significant predictor of a favourable clinical outcome by Cox regression analysis, adjusting for classical predictors of poor outcome after AMI. CONCLUSION: Intracoronary administration of BMCs is associated with a significant reduction of the occurrence of major adverse cardiovascular events after AMI. Large-scale studies are warranted to confirm the effects of BMC administration on mortality and morbidity in patients with AMIs.

[drjoe]

But how do stem cells do in the infarcted area? what is the mechanis of action?

[jane]

to help me to have better understanding, can someone please explain on this:

-----administration of bone-marrow-derived progenitor cells in acute myocardial infarction

thank you

[kkmalaysia]

I personally don't think it can really work. How can progenitor cells help to regenerate heart muscles which are dead?

[guchikukoru]

What are the other uses of sterm cells? What is sterm cell?

[aliun]

Awesome

[Admin]

(post by AndreY on: July 23, 2008, 02:03:14 PM)

Very awesome.