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Author Topic: Prostate cancer, T3N1M1, st. 4  (Read 20 times)
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octabrain Topic starter
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« on: January 27, 2012, 10:04:41 pm »

Hi! I'm from Russia, so please excuse me for my bad English.

My father has a prostate cancer diagnosed in Jun, 2010. Complications: chronic pyelonephritis, 1st grade renal insufficiency. Ñoncomitant diseases: ischemic heart disease, stenocardia, atherosclerotic cardiosclerosis, 2nd grade hipertensive disease.

He is 70 y.o. He complains of growing weakness, often increasings of blood pressure (170/100 mmHg), sometimes increased body temperature (38 Celsius/100.4 Fahrenheit). Biopsy: tumor fragments have a structere of low-grade differentiated mucocellular adenocarcinoma, Gleason pattern 5 first and second grade (equal 10). US, MRI and CT (Jun. 2010): metasteses in pelvis, retroperitoneal, iliac, intrathoracic, supraclavicular lymph nodes and bones (L2 vertebra).

05.14.2010: bilateral through-skin puncture nephrostoma (one of them had fallen in Oct, 2010).

06.09.2010: PSA=374.30 ng/ml

06.29.2010: bilateral orchectomy, from 07.05.2010 Flutamide 250 mg triple per day.

08.27.2010: PSA=77.66 ng/ml
10.01.2010: PSA=63.133 ng/ml
11.29.2010: PSA=40.68 ng/ml
01.14.2011: PSA=63.14 ng/ml;
from 01.22.2011 Bicalutamide 50 mg once per day.
02.18.2011: PSA=68.28 ng/ml
04.01.2011: PSA=28.27 ng/ml
05.07.2011: PSA=17.36 ng/ml
07.20.2011: PSA=20.1 ng/ml;
in Aug and Sep 2011 - taking of Bicalutamide interrupted.
08.18.2011: PSA=20.30.
09.19.2011: PSA=28.03;
in Oct taking of Bicalutamide resumed, 50 mg once per day.
11.18.2011: PSA=28.848 ng/ml
01.19.2012: PSA=48.55

Could you tell me what must we do?
1. What variant of treatment should I discuss with therapist?
2. Should we continue of taking of Bicalutamide 50 mg?

Sincerely,
Alexander
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