Prostate cancer, T3N1M1, st. 4

[octabrain]

Hi! I'm from Russia, so please excuse me for my bad English.

My father has a prostate cancer diagnosed in Jun, 2010. Complications: chronic pyelonephritis, 1st grade renal insufficiency. Ñoncomitant diseases: ischemic heart disease, stenocardia, atherosclerotic cardiosclerosis, 2nd grade hipertensive disease.

He is 70 y.o. He complains of growing weakness, often increasings of blood pressure (170/100 mmHg), sometimes increased body temperature (38 Celsius/100.4 Fahrenheit). Biopsy: tumor fragments have a structere of low-grade differentiated mucocellular adenocarcinoma, Gleason pattern 5 first and second grade (equal 10). US, MRI and CT (Jun. 2010): metasteses in pelvis, retroperitoneal, iliac, intrathoracic, supraclavicular lymph nodes and bones (L2 vertebra).

05.14.2010: bilateral through-skin puncture nephrostoma (one of them had fallen in Oct, 2010).

06.09.2010: PSA=374.30 ng/ml

06.29.2010: bilateral orchectomy, from 07.05.2010 Flutamide 250 mg triple per day.

08.27.2010: PSA=77.66 ng/ml
10.01.2010: PSA=63.133 ng/ml
11.29.2010: PSA=40.68 ng/ml
01.14.2011: PSA=63.14 ng/ml;
from 01.22.2011 Bicalutamide 50 mg once per day.
02.18.2011: PSA=68.28 ng/ml
04.01.2011: PSA=28.27 ng/ml
05.07.2011: PSA=17.36 ng/ml
07.20.2011: PSA=20.1 ng/ml;
in Aug and Sep 2011 - taking of Bicalutamide interrupted.
08.18.2011: PSA=20.30.
09.19.2011: PSA=28.03;
in Oct taking of Bicalutamide resumed, 50 mg once per day.
11.18.2011: PSA=28.848 ng/ml
01.19.2012: PSA=48.55

Could you tell me what must we do?
1. What variant of treatment should I discuss with therapist?
2. Should we continue of taking of Bicalutamide 50 mg?

Sincerely,
Alexander

[Kelley]

There are some signs of prostate cancer that you need to look for as you are caring for your health and working to prevent serious issues like. Most men will show some symptom of prostate cancer before their doctor will give them an official diagnosis.